i know someone who uses ADHD medicine, so i was curious as to what the difference between the two types of medicine ingredients used are:
* methylphenidate
* amphetamnine
  
after reading alot today i think i've broken down the difference between the two:
methylphenidate (medicines like concerta and ritalin):
* blocks reuptake of dopamine (DRI)
* increases the body's production of dopamine, but to a less extent than amphetamine 
amphetamine:
* slows reuptake of dopamine
"acts as a substrate for DAT and slows reuptake by a secondary acting 
mechanism through the phosphorylation of dopamine transporters." 
 
* increases the body's production of dopamine (RA)
they seem really similar--their 2 main effects are inversely stronger than the other.
UPDATE 20131001
Here's some feedback about the subject from a pharmacist friend of mine in the US:
"
You're spot on with regards to the chemical 
action/brain chemistry.  Dopamine is the main target, whether that be by
 blocking reabsorption or increasing production, but there is some 
norepinephrine activity with both as well.  Two main characteristics 
that I think contribute to clinical efficacy with both is how your body 
metabolizes the drug and the drugs respective half life.  The 
amphetamine salts have an active metabolite, meaning the drug has to be 
chemically changed through metabolism to an active form, in this case 
dextroamphetamine before it exerts an effect.  Adderall is formulated in
 about a 25/75 ratio of amphet/dextroamphet.  This process happens in 
the liver, and why the phosphorylation that you mentioned in your blog 
is important . Much more importantly in my opinion though is that 
methylphenidate has a much shorter half-life, 2-3 hours for the 
immediate release formulation (Ritalin) and 4-5 hours for the extended 
release formulation (Concerta, Focalin).  Amphetamine salts have a half 
life of up 14 hours, depending on liver function.  Longer half life 
means longer dosing intervals, which leads to better patient compliance 
which leads to better clinical outcomes.  Ritalin IR has to be dosed two
 to three times daily and leads to a peak/trough drug level effect which
 is not ideal.  This effect led to development of an ER formulation of 
methylphenidate.  Concerta is ER, so can be dosed once daily, but with a
 short half life still poses more of a peak/trough effect compared to 
Adderall and dosage increase is often warranted to get trough levels to 
stay above the therapeutic level. Adderall is also dosed once daily, but
 with a longer half-life, typically dosing is more stable and drug levels 
avoid that peak/trough effect.  Of course, both drugs a highly addictive
 and are habit-forming, which I think leads to a big part of the social 
stigma here in the states.  (despite the same addiction potential of 
alcohol, tobacco, marijuana, etc stimulant drugs are almost seen as 
taboo to some)
Hope that gives a little more insight or something 
to further research.  Medicine is as much of an art as it is a science, 
if something works well for some, it doesn't necessarily extrapolate to 
you.  Find what works well for you, fine tune the dosing and you'll be 
well on your way.
"
Subscribe to:
Post Comments (Atom)
 








 



No comments:
Post a Comment