i know someone who uses ADHD medicine, so i was curious as to what the difference between the two types of medicine ingredients used are:
* methylphenidate
* amphetamnine
after reading alot today i think i've broken down the difference between the two:
methylphenidate (medicines like concerta and ritalin):
* blocks reuptake of dopamine (DRI)
* increases the body's production of dopamine, but to a less extent than amphetamine
amphetamine:
* slows reuptake of dopamine
"acts as a substrate for DAT and slows reuptake by a secondary acting
mechanism through the phosphorylation of dopamine transporters."
* increases the body's production of dopamine (RA)
they seem really similar--their 2 main effects are inversely stronger than the other.
UPDATE 20131001
Here's some feedback about the subject from a pharmacist friend of mine in the US:
"
You're spot on with regards to the chemical
action/brain chemistry. Dopamine is the main target, whether that be by
blocking reabsorption or increasing production, but there is some
norepinephrine activity with both as well. Two main characteristics
that I think contribute to clinical efficacy with both is how your body
metabolizes the drug and the drugs respective half life. The
amphetamine salts have an active metabolite, meaning the drug has to be
chemically changed through metabolism to an active form, in this case
dextroamphetamine before it exerts an effect. Adderall is formulated in
about a 25/75 ratio of amphet/dextroamphet. This process happens in
the liver, and why the phosphorylation that you mentioned in your blog
is important . Much more importantly in my opinion though is that
methylphenidate has a much shorter half-life, 2-3 hours for the
immediate release formulation (Ritalin) and 4-5 hours for the extended
release formulation (Concerta, Focalin). Amphetamine salts have a half
life of up 14 hours, depending on liver function. Longer half life
means longer dosing intervals, which leads to better patient compliance
which leads to better clinical outcomes. Ritalin IR has to be dosed two
to three times daily and leads to a peak/trough drug level effect which
is not ideal. This effect led to development of an ER formulation of
methylphenidate. Concerta is ER, so can be dosed once daily, but with a
short half life still poses more of a peak/trough effect compared to
Adderall and dosage increase is often warranted to get trough levels to
stay above the therapeutic level. Adderall is also dosed once daily, but
with a longer half-life, typically dosing is more stable and drug levels
avoid that peak/trough effect. Of course, both drugs a highly addictive
and are habit-forming, which I think leads to a big part of the social
stigma here in the states. (despite the same addiction potential of
alcohol, tobacco, marijuana, etc stimulant drugs are almost seen as
taboo to some)
Hope that gives a little more insight or something
to further research. Medicine is as much of an art as it is a science,
if something works well for some, it doesn't necessarily extrapolate to
you. Find what works well for you, fine tune the dosing and you'll be
well on your way.
"
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